EMUS-TWIN (ElectroMagnetic Ultrasonic Sensors coupled with Physics-Informed Digital TWIN for Real-Time Integrity Evaluation) develops a physics-informed digital twin for monitoring fatigue damage in nuclear power plant piping, accounting for defects. A tomographic EMUS-based inspection system captures stress fields and defects from multiple angles enabling an inverse reconstruction algorithm that continuously calibrates the digital twin. Acting as a “virtual sensor” for inaccessible areas, it bridges knowledge gaps in fatigue monitoring. It will support predictive maintenance, with potential to reduce operational costs, personnel exposure and unplanned outages, reinforcing regulatory and LTO support.